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ANDREEFF, MICHAEL
One or more keywords matched the following items that are connected to ANDREEFF, MICHAEL
Item TypeName
Academic Article MEK inhibition enhances ABT-737-induced leukemia cell apoptosis via prevention of ERK-activated MCL-1 induction and modulation of MCL-1/BIM complex.
Concept MAP Kinase Kinase 2
Concept Mitogen-Activated Protein Kinase Kinases
Concept MAP Kinase Kinase Kinases
Concept MAP Kinase Kinase 4
Concept MAP Kinase Kinase 1
Academic Article Evaluation of apoptosis induction by concomitant inhibition of MEK, mTOR, and Bcl-2 in human acute myelogenous leukemia cells.
Academic Article MEK blockade converts AML differentiating response to retinoids into extensive apoptosis.
Academic Article Therapeutic targeting of the MEK/MAPK signal transduction module in acute myeloid leukemia.
Academic Article The mitogen-activated protein kinase signaling module as a therapeutic target in hematologic malignancies.
Academic Article Beyond single pathway inhibition: MEK inhibitors as a platform for the development of pharmacological combinations with synergistic anti-leukemic effects.
Academic Article Therapeutic potential of MEK inhibition in acute myelogenous leukemia: rationale for "vertical" and "lateral" combination strategies.
Academic Article Synergistic induction of apoptosis by simultaneous disruption of the Bcl-2 and MEK/MAPK pathways in acute myelogenous leukemia.
Academic Article Leukotriene B4 receptor inhibitor LY293111 induces cell cycle arrest and apoptosis in human anaplastic large-cell lymphoma cells via JNK phosphorylation.
Academic Article Activation of integrin-linked kinase is a critical prosurvival pathway induced in leukemic cells by bone marrow-derived stromal cells.
Academic Article Mitogen-activated protein kinase kinase inhibition enhances nuclear proapoptotic function of p53 in acute myelogenous leukemia cells.
Academic Article Activation of FOXO3a is sufficient to reverse mitogen-activated protein/extracellular signal-regulated kinase kinase inhibitor chemoresistance in human cancer.
Academic Article PTEN status is a crucial determinant of the functional outcome of combined MEK and mTOR inhibition in cancer.
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  • Mitogen Activated Protein Kinase Kinases